公司簡介

公司介紹//Introduction

深圳市艾斯基因科技有限公司專注表觀組學技術創新及臨床醫學轉化應用10年，核心團隊在Nature Communications、Genome Biology、Cell Research、Genome Med、Development、PNAS、Clinical Epigenetics、Epigenetics等期刊發表40余篇論文。

在科研技術服務上，提供DNA甲基化為核心的表觀實驗和信息分析技術服務。每年為海外客戶、國內渠道客戶及終端客戶提供10000+例樣本的技術服務。在醫學轉化應用上, 開展5mC和5hmC為biomarker的疾病分子分型及早篩早診，提供循環腫瘤DNA、糞便、尿液、肺泡灌洗液、病理切片及穿刺活檢等樣本的完整解決方案。

團隊成員署名的文章列表//article

[1] Estrogen Accelerates Heart Regeneration by Promoting the Inflammatory Response in Zebrafish. J Endocrinol. 2020 Apr;245(1):39-51. 
[2] Precise Drug Delivery by Using PLGA-Based Microspheres and Optical Manipulators. IEEE Trans Nanobioscience. 2020 Apr;19(2):192-202. 
[3] Exposure to Phthalates Impaired Neurodevelopment Through Estrogenic Effects and Induced DNA Damage in Neurons. Aquat Toxicol. 2020 May;222:105469.
[4] Cilia-driven Asymmetric Hedgehog Signalling Determines the Amphioxus Left-Right Axis by Controlling Dand5 Expression. Development . 2020 Jan 13;147(1):dev182469.
[5] Excessive Inflammation Impairs Heart Regeneration in Zebrafish Breakdance Mutant After Cryoinjury. Fish Shellfish Immunol. 2019 Jun;89:117-126.
[6] Interplay Between Lefty and Nodal Signaling Is Essential for the Organizer and Axial Formation in Amphioxus Embryos. Dev Biol. 2019 Dec 1;456(1):63-73. 
[7] An Effective Microinjection Method and TALEN-Mediated Genome Editing in Pacific Abalone. Mar Biotechnol (NY) . 2019 Aug;21(4):441-447
[8] Facile Preparation of Carbon Shells-Coated O-Doped Molybdenum Carbide Nanoparticles as High Selective Electrocatalysts for Nitrogen Reduction Reaction Under Ambient Conditions. ACS Appl Mater Interfaces. 2019 Sep 4;11(35):31869-31877.
[9] Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer. Clin Epigenetics. 2018;10:30.(IF=4.327)
[10] Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. DNA Res. 2018 Jan 19.(IF=5.415)
[11] Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction. Mol Genet Genomics. 2018;293(4):807-818.(IF=2.979)
[12] Spectroscopic Examination of Enamel Staining by Coffee Indicates Dentin Erosion by Sequestration of Elements. Talanta. 2018 Nov 1;189:550-559. 
[13] Matrix Metalloproteinases (MMPs) Mediate Leukocyte Recruitment During the Inflammatory Phase of Zebrafish Heart Regeneration. Sci Rep. 2018 May 8;8(1):7199. 
[14] The association of changes in DNA methylation with temperature-dependent sex determination in cucumber. Journal of Experimental Botany. 2017;68(11):2899-2912.(IF=5.83)
[15] De novo DNA methylation during monkey pre-implantation embryogenesis. Cell Research. 2017;27:526-539. (IF=14.812)
[16] DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. Genome Med. 2017;24;9(1):28.(IF=8.898)
[17] Cerberus-Nodal-Lefty-Pitx signaling cascade controls left-right asymmetry in amphioxus. Proc Natl Acad Sci USA. 2017;114(14):3684-3689.(IF= 9.15)
[18] Hedgehog Participates in the Establishment of Left-Right Asymmetry During Amphioxus Development by Controlling Cerberus Expression. Development. 2017 Dec 15;144(24):4694-4703. 
[19]    Novel regional age-associated DNA methylation changes within human common disease-associated loci. Genome biology. 2016; 17: 193.(IF=11.313)
[20]    Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue. Scientific reports. 2016; 6: 31826.(IF=5.228)
[21]    Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins. The Journal of clinical endocrinology and metabolism. 2016; 101: 2450-9.(IF=5.531)
[22] DNA methylation landscape of fat deposits and fatty acid compositionin obese and lean pigs. Scientific Reports. 2016;6:35063.(IF=5.228)
[23] Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Scientific reports. 2016; 6: 31088.(IF=5.228)
[24] The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns. Scientific reports. 2016; 6:20181.(IF=5.228)
[25] Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach. Clin Epigenetics. 2015;7:86. (IF=4.327)
[26]    Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells. Epigenomics. 2015; 7: 47-56.(IF=4.044)
[27]    A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer. Journal of pharmaceutical and biomedical analysis. 2015; 102: 500-8.(IF=3.169)
[28]    Clustering of Cancer Cell Lines Using A Promoter- Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach. Technology in cancer research & treatment. 2015; 14: 383-94. (IF=2.185)
[29]    Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. Genome biology. 2014; 15: 533.(IF=11.313)
[30]    Marked methylation changes in intestinal genes during the perinatal period of preterm neonates. BMC genomics. 2014; 15: 716.(IF=3.867)
[31]    A 20-gene signature in predicting the chemoresistance of breast cancer to taxane-based chemotherapy. Molecular bioSystems. 2014; 10: 3111-9.(IF=2.829)
[32]    Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs. BMC genomics. 2014; 15: 653.(IF=3.867)
[33] An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature communications. 2014; 5: 5719.(IF=11.329)
[34]    DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype. Journal of autoimmunity. 2014; 54: 127-36.(IF=7.76)
[35] Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. Genome biology. 2014;15(4):R56.(IF=11.313)
[36] Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes. Nature communications. 2014; 5:5896.(IF=11.329)
[37] Decelerated Genome Evolution in Modern Vertebrates Revealed by Analysis of Multiple Lancelet Genomes. Nat Commun. 2014 Dec 19;5:5896. (IF=11.329)
[38] High-throughput sequencing of methylated cytosine enriched by modification-dependent restriction endonuclease MspJI. BMC Genetics. 2013;14:56.(IF=2.152)
[39]    Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing. BMC genomics. 2013; 14: 11.(IF=3.867)
[40]    Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells. PloS one. 2013; 8: e64954.(IF=3.057)
[41]    Hydroxymethylation- and methylation-sensitive tag sequencing: how will this technology change clinical applications of DNA methylation profiling? Epigenomics. 2013; 5: 355-7.(IF=4.044)
[42]    Integrated detection of both 5-mC and 5-hmC by high-throughput tag sequencing technology highlights methylation reprogramming of bivalent genes during cellular differentiation. Epigenetics. 2013; 8: 421-30.(IF=4.327)
[43]    Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis. Genome biology. 2012; 13: R100.(IF=11.313)
[44]    An atlas of DNA methylomes in porcine adipose and muscle tissues. Nature communications. 2012; 3: 850.(IF=11.329)
[45]    Co-methylated genes in different adipose depots of pig are associated with metabolic, inflammatory and immune processes. International journal of biological sciences. 2012; 8: 831-7.(IF=3.982)
[46] The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates. Mol Biol Evol. 2009; 26(7):1619-30.(IF=10.217)
[47] Comparison of Pax1/9 locus reveals 500-Myr-old syntenic block and evolutionary conserved noncoding regions. Mol Biol Evol. 2007;24(3):784-91.(IF=10.217)